The word aphaeresis or Hemopheresis means separately and aphaeresis a word from Greek vocabulary with a meaning of separate or outside. The basis of this word is partially from blood which seponat from a donor. From example, if plasmas separate from blood the word plasmapherese is commonly used and this method has great effect in curing 50 or more patiants. Plasmaphersis is cure in patients with Myasthenia grew is and serdrom glem has use in adults and youth regarless, plasmapheresis was innovated for the first time in 1914 beet because of short age in mechanical machine to perform the separation it get limit and reason is to separate and harvest a liter of plasma a lease 5 hours was needed. Like other curing method plasmapheresis has good potential and side effect which need lot affection. One the big side effect in youth during plasmapherese. Decrease in blood pressure and its symptoms are Fainting, dizziness, blurriness in sight, cramps in abs and lower stomach and easiest ways to fix this situafion is to put the patienths. In a shock and inject with liquids. The factors in decreasing blood pressure: Mosley of light weight, young age, tumors illness in kidneys, having less blood during plasmapheresis if needs. Hypoglycemia and Hemoglobin is previously done it its low .One of the circumstauce is catheter in which is catheter sub clavien and the serious domuges that it could Imply are internal bleeding, hung damage and getting infected during long use and this infection could turn in to poison which could very dangerous for kids underage or if they are in intensive care. The other eircumstances during procedure is holding the blood outside of the body which citrate is used to prevent. Citrate will bawd itself with calcium which causes the holding of the blood, citrate with lower the blood calcium which could use this prevention during plasmapherese and could be used as food and this method 3/4 till 28% has been reported. Other symtons Anomie, technical problem and agitation , shivers and fever, nausea , vomiting, hemolysis, heart rhythmic , hung problem and even death has been announced. During recect reseauh in france the death rate 0.0017 till 0.0009 for each patient and 0.019 till 0.01 for each procedure has been reported so the risk factors of plasma pheresis in children is because of yang age, intensive care and decrease in hemoglobin and how many time this procedure was dore which the nurse has to keep a close attention in case of emergercy.